Objective: Use Lead-DBS software to analyze stereotactical surgical outcome of an operated population and demonstrate that small target deviations do not compromise the stimulation of desired structures, even with small amperages.
Methods: Image exams of patients submitted to deep brain stimulation for movement disorders treatment were processed in Lead-DBS software. Electrode stereotactic coordinates were subtracted from the planned target and those deviations, compared among different anatomical targets and sides operated firstly and secondly. We also quantified the frequency of relation between the activated tissue volume and the planned target through computer simulations.
Results: None of the 16 electrodes were exactly implanted at the planned coordinates. A stimulation of 3 mA reached 62.5% of the times the planned coordinates, rising to 68.75% with a 3,5 mA. No statistical significance was demonstrated in any comparison of laterality and anatomical sites.
Conclusions: The simulation of small amperage fields could reach the intended target even when electrode placement is suboptimal. Furthermore, such a goal can be achieved without overlapping the volume of activated tissue with undesired structures. Software Lead-DBS proved to be a valuable complementary asset for surgical stereotactical result assessment.
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Article Synopsis
- The study evaluated the effectiveness of bilateral GPi deep brain stimulation (DBS) for treating benign essential blepharospasm (BEB) and complete Meige syndrome in 36 patients over an extended period from 2014 to 2022.
- Post-surgery assessments indicated significant improvements in symptom severity for both conditions, with BEB patients showing an average improvement of 60.3% and 69.7% at six months and final follow-up, respectively.
- Additionally, the researchers analyzed the correlation between different GPi subregions and symptom improvement, although they did not find significant prognostic correlations overall.
[Influential factors of non-motor symptoms prognosis in Parkinson's disease patients undergoing deep brain stimulation].
Zhonghua Yi Xue Za Zhi
December 2023
Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
To investigate the effects of electrode activated contact location, volume of tissue activated (VTA) and age on non-motor symptoms, such as emotional symptoms and cognitive function, in Parkinson's disease (PD) patients with deep brain stimulation (DBS). PD patients who underwent DBS of subthalamic nucleus (STN) at the Department of Functional Neurosurgery of Beijing Tiantan Hospital from September 1, 2020 to August 31, 2022 were retrospectively enrolled. The International Parkinson and Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Montreal Cognitive Assessment (MoCA), and Mini-Mental State Examination Scales (MMSE) were used at the preoperative, 1-month and 12-month postoperative time points.
View Article and Find Full Text PDFInitial case series of a novel sensing deep brain stimulation device in drug-resistant epilepsy and consistent identification of alpha/beta oscillatory activity: A feasibility study.
Epilepsia
October 2023
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Objective: Here, we report a retrospective, single-center experience with a novel deep brain stimulation (DBS) device capable of chronic local field potential (LFP) recording in drug-resistant epilepsy (DRE) and explore potential electrophysiological biomarkers that may aid DBS programming and outcome tracking.
Methods: Five patients with DRE underwent thalamic DBS, targeting either the bilateral anterior (n = 3) or centromedian (n = 2) nuclei. Postoperative electrode lead localizations were visualized in Lead-DBS software.
Deep Brain Stimulation Electrode Reconstruction: Comparison between Lead-DBS and Surgical Planning System.
J Clin Med
February 2023
Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Background: Electrode reconstruction for postoperative deep brain simulation (DBS) can be achieved manually using a surgical planning system such as Surgiplan, or in a semi-automated manner using software such as the Lead-DBS toolbox. However, the accuracy of Lead-DBS has not been thoroughly addressed.
Methods: In our study, we compared the DBS reconstruction results of Lead-DBS and Surgiplan.
Accurate Deep Brain Stimulation Lead Placement Concurrent With Research Electrocorticography.
Oper Neurosurg (Hagerstown)
May 2023
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Background: Using electrocorticography for research (R-ECoG) during deep brain stimulation (DBS) surgery has advanced our understanding of human cortical-basal ganglia neurophysiology and mechanisms of therapeutic circuit modulation. The safety of R-ECoG has been established, but potential effects of temporary ECoG strip placement on targeting accuracy have not been reported.
Objective: To determine whether temporary subdural electrode strip placement during DBS implantation surgery affects lead implantation accuracy.
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