AI Article Synopsis
- Three perylene bisimide-glycopeptide conjugates were created, showing moderate effectiveness in controlling ice crystal growth.
- These conjugates, particularly PBI-AFF-Glu, significantly enhanced cell viability during cryopreservation, achieving 22.77% for HeLa cells, 19.43% for A549 cells, and 16.63% for GES-1 cells at a concentration of 1.0 mg/mL.
- The findings aim to aid in the future development of self-assembled cryoprotectants for preserving cells.
Article Abstract
Three perylene bisimide-glycopeptide conjugates (PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal) were synthesized, which showed moderate activity in the control of ice crystal growth. Furthermore, the cellular cryopreservation effects of PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal showed enhancements in cell viabilities, especially for PBI-AFF-Glu with values of 22.77 ± 3.33% (HeLa cells), 19.43 ± 1.90% (A549 cells) and 16.63 ± 1.76% (GES-1 cells) at a dose of 1.0 mg mL. This work will help guide the development of self-assembled cryoprotectants.
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| http://dx.doi.org/10.1039/d1cc03835d | DOI Listing |
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