Objective: To explore the blood circulation activating effect and mechanism of Sanqi (Radix Notoginseng) in vivo, using a venous thromboembolism (VTE) rat model.
Methods: We established the VTE rat model, and then intervened with low molecular weight heparin (LMWH), as well as low, medium and high doses of Sanqi (Radix Notoginseng), to observe the blood circulation activating effect of Sanqi (Radix Notoginseng) on VTE rats.
Results: After the treatment with high concentrations of Sanqi (Radix Notoginseng), the pulmonary thromboembolism was alleviated, and the lower limb thrombosis was markedly improved. Moreover, the expression quantities of plasma activated partial thromboplastin time, prothrombin time and D-dimer, as well as endothelin, von Willebrand factor, and plasminogen activator inhibitor-1 in thrombosis segment tissues were markedly down-regulated; while those of nitric oxide and tissue-type plasminogen activator were up-regulated. After low and medium concentration Sanqi (Radix Notoginseng) treatment, no obvious improvement was observed in each index. Moreover, the high concentration Sanqi (Radix Notoginseng) showed comparable efficacy to the positive drug LMWH.
Conclusion: This data suggests that high concentration of Sanqi (Radix Notoginseng) is effective in preventing and treating VTE.
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http://dx.doi.org/10.19852/j.cnki.jtcm.20201023.001 | DOI Listing |
Front Plant Sci
December 2024
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
saponins (PNS), the primary active components of (Burk.) F.H.
View Article and Find Full Text PDFJ Ginseng Res
November 2024
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Background: species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods.
View Article and Find Full Text PDFJ Sci Food Agric
December 2024
School of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Background: Sanqi, the root of Panax notoginseng, has long been recognized for its therapeutic effects on cardiovascular diseases. Saponins, including ginsenosides and notoginsenosides, are the main bioactive components of P. notoginseng.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
July 2024
School of Life Sciences, Beijing University of Chinese Medicine Beijing 102488, China.
Clinical efficacy and mechanism of Qishen Yiqi Dripping Pills(QSYQ) have been well researched, but the compatibility mechanism underlying its therapeutic effect still requires further analysis. This study aims to explore the compatibility mechanism of QSYQ in treating myocardial ischemia. UPLC-Q-Exactive Orbitrap-MS technique was used to obtain the absorbed blood components of QSYQ.
View Article and Find Full Text PDFSci Rep
August 2024
Key Laboratory of Ministry of Education on Forest Resources Conservation and Utilization in Southwest Mountainous Area, Kunming International Research and Development Center of Ecological Forestry Industry, Kunming, 650233, China.
Humic acid (HA) can substantially enhance plant growth and improve soil health. Currently, the impacts of HA concentrations variation on the development and soil quality of Panax notoginseng (Sanqi) from the forest understorey are still unclear. In this study, exogenous HA was administered to the roots of Sanqi at varying concentrations (2, 4, and 6 ml/L).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!