AI Article Synopsis
- The study aimed to understand how certain proteins contribute to drug resistance in HIV-infected individuals in Africa.
- Cell membrane proteins from forty HIV-positive patients were analyzed using a technique called HPLC-MS to identify which proteins are linked to drug resistance and disease severity.
- Key findings included the presence of heat shock proteins and pH-responsive proteins in different isolates, along with various mechanisms that help pathogens evade treatment, suggesting a complex relationship between these proteins and drug resistance in HIV patients.
Article Abstract
The objective of this study was to elucidate the proteomic mechanisms of drug resistance in HIV-infected African patients. Cell membrane fractions from forty oral isolates isolated from African HIV-positive patients were analysed using HPLC-MS with the aim of identifying proteins associated with their pathogenicity and drug resistance. Heat shock proteins that mediate the fungicidal activity of salivary peptides were found in all tested fractions, with pH-responsive proteins associated with increased pathogenicity only being present in the three most commonly isolated species. ABC multidrug transporter efflux pumps and estrogen binding proteins were only found in fractions, while ergosterol biosynthesis proteins were identified in four species. The combination of various adherence, invasion, upregulation and efflux pump mechanisms appear to be instrumental for the host colonization and drug resistance emergence in HIV-infected individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500794 | PMC |
| http://dx.doi.org/10.3934/microbiol.2021020 | DOI Listing |
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