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Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia. | LitMetric

AI Article Synopsis

  • The study aimed to explore immune profiles in patients with benign prostatic hyperplasia (BPH) by measuring lymphocyte subsets and T cell proportions.
  • Results showed significant reductions in CD3, CD4, and CD8 T cells in BPH patients, while NK and B cells remained unchanged.
  • The findings suggest that immune dysfunction related to BPH may increase the risk of infections and tumor development, potentially contributing to the progression towards prostate cancer.

Article Abstract

Objective: To investigate the immune profiles in benign prostatic hyperplasia, changes in the absolute number of lymphocyte subsets and the proportion of T lymphocyte subsets were detected.

Methods: Absolute value of lymphocyte subsets in peripheral blood (T, B and NK cells) and the proportion of T lymphocyte (native CD4 T cell, memory CD4 T cell, CD8CD28 T cell, CD8CDDR T cells and CD8CD38 T cell) were measured by flow cytometry.

Results: The absolute values of CD3 T cell (972.55±330.31 vs 1757.99±439.38), CD4 T cell (656.43±252.39 vs 899.30±262.10), and CD8 T cell (301.97±147.76 vs 728.45±230.34) in patients with benign prostatic hyperplasia were significantly reduced (all <0.05). There was no significant difference in NK cell (285.58±182.84 vs 528.92±208.17) and B cell (186.66±86.62 vs 334.17±130.46). The proportion of naive CD4 T cell (3.75±0.50 vs 8.54±1.61) in T lymphocyte subsets in patients with BPH was significantly reduced (<0.05). There was no significant difference in memory CD4 T cell (87.9±6.37 vs 92.63±5.94), CD8CD28 T cell (60.52±13.86 vs 64.32±12.78), CD8CDDR T cell (36.58±12.87 vs 31.92±8.54) and CD8CD38 T cell (2.1±1.90 vs 2.55±2.01).

Conclusion: Immune dysfunction raised the risk of viral infection, inflammatory stimulation, and tumor induction in prostate cells, leading to hyperplasia, and immune non-response was potentially a key factor in the transformation of BPH into prostate cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542518PMC
http://dx.doi.org/10.2147/IJGM.S340018DOI Listing

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