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A chimeric anti-vascularization immunomodulator prevents high-risk corneal transplantation rejection via ex vivo gene therapy.
Mol Ther
November 2024
Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bedrock Therapeutics, Raleigh, NC 27613, USA. Electronic address:
Corneal blindness affects more than 5 million individuals, with over 180,000 corneal transplantations (CTs) performed annually. In high-risk CTs, almost all grafts are rejected within 10 years. Here, we investigated adeno-associated virus (AAV) ex vivo gene therapy to establish immune tolerance in the corneal allograft to prevent high-risk CT rejection.
View Article and Find Full Text PDFDiagnosis and treatment of traumatic Descemet's membrane detachment: A case series.
Medicine (Baltimore)
June 2023
PLA General Hospital Jingxi Medical Area, Beijing, China.
Rationale: The Descemet layer is a dense layer of tissue that does not detach under normal circumstances. Descemet layer detachment may occur after intraocular surgery, but the Descemet layer spontaneously detached after trauma in this child, which is relatively rare. After looking for the cause, we found that the child was diagnosed with congenital glaucoma, and the trauma induced the Descemet's membrane detachment.
View Article and Find Full Text PDFCataract Surgery in Malignant Glaucoma from Complete Subluxation of Lens into Anterior Chamber.
J Curr Glaucoma Pract
January 2021
Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, USA.
Aim And Objective: To report an unusual and difficult case of malignant glaucoma induced by a traumatic mature cataract that had migrated into the anterior chamber in a developmentally delayed patient.
Background: Malignant glaucoma can present due to multiple mechanisms, including trauma-induced cataract migration into the anterior chamber.
Case Description: A developmentally delayed female in her 40s with a history of self-abuse was found to have malignant glaucoma in the setting of a traumatic cataract that had migrated in front of the iris into the anterior chamber.
[Trauma-induced Corneal Ectasia: the Interesting Case].
Klin Monbl Augenheilkd
February 2022
Ophthalmologisches Institut für Augenheilkunde und Mikrochirurgie, Ophthalmica Clinic, Thessaloniki, Griechenland.
Effect of intraoperative optical coherence tomography on anatomic and cosmetic results of intrastromal tattooing.
Saudi J Ophthalmol
September 2021
Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Purpose: The aim of the study was to evaluate the effect of intraoperative optical coherence tomography (i-OCT) on anatomic and cosmetic outcomes of intrastromal keratopigmentation (i-KTP) performed by novice lamellar corneal surgeons.
Methods: Thirty patients presenting with unilaterally disfiguring corneal scar and nil visual prognosis were subjected to i-OCT-guided intrastromal tattooing with rotring ink, by ophthalmology residents undergoing training in corneal surgeries at our center, who were later asked for a subjective feedback and mean stromal depth dissected was measured objectively. All patients were followed up for 9 months after surgery, and the subjective satisfaction of the patient, an independent observer, and surgeon was graded as poor, good, and excellent.
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