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Functional characterization of the DUF1127-containing small protein YjiS of Typhimurium.
Microlife
January 2025
Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), D-97080 Würzburg, Germany.
Bacterial small proteins impact diverse physiological processes, however, technical challenges posed by small size hampered their systematic identification and biochemical characterization. In our quest to uncover small proteins relevant for pathogenicity, we previously identified YjiS, a 54 amino acid protein, which is strongly induced during this pathogen's intracellular infection stage. Here, we set out to further characterize the role of YjiS.
View Article and Find Full Text PDFCommutability assessment of new standard reference materials (SRMs) for determining serum total 25-hydroxyvitamin D using ligand binding and liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays.
Anal Bioanal Chem
January 2025
Chemical Sciences Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, 20899, USA.
Commutability is where the measurement response for a reference material (RM) is the same as for an individual patient sample with the same concentration of analyte measured using two or more measurement systems. Assessment of commutability is essential when the RM is used in a calibration hierarchy or to ensure that clinical measurements are comparable across different measurement procedures and at different times. The commutability of three new Standard Reference Materials (SRMs) for determining serum total 25-hydroxyvitamin D [25(OH)D], defined as the sum of 25-hydroxyvitamin D [25(OH)D] and 25-hydroxyvitamin D [25(OH)D], was assessed through an interlaboratory study.
View Article and Find Full Text PDFMulti-dimensional analyses identify genes of high priority for pancreatic cancer research.
JCI Insight
January 2025
Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, United States of America.
Pancreatic ductal adenocarcinoma (PDAC) is a drug resistant and lethal cancer. Identification of the genes that consistently show altered expression across patients' cohorts can expose effective therapeutic targets and strategies. To identify such genes, we separately analyzed five human PDAC microarray datasets.
View Article and Find Full Text PDFG9a/GLP Modulators: Inhibitors to Degraders.
J Med Chem
January 2025
SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Article Synopsis
- Histone methylation is a key part of epigenetics, involving enzymes like G9a that modify histones and regulate DNA processes such as replication and gene expression.
- Overexpression of G9a is linked to cancer development and progression, making it an appealing target for new cancer therapies.
- Research is also uncovering the role of G9a in diseases like Alzheimer's, leading to the development of G9a inhibitors that could treat various conditions by disrupting harmful signaling pathways.
identification of Nipah virus protein inhibitors from secondary metabolites of medicinal plants using a high-throughput virtual screening approach.
J Biomol Struct Dyn
December 2024
Department of Science and Technology, Virology and Vaccine Research Program, Industrial Technology Development Institute, Taguig City, Philippines.
The Nipah virus (NiV), a highly pathogenic zoonotic virus of the family, poses significant threats with its alarming mortality rates and pandemic potential. Despite historical cases, effective therapeutics remain elusive, prompting urgent exploration of potential antivirals. In this study, a structure-based virtual screening approach was employed to evaluate 690 metabolites sourced from ten medicinal plants () for their antiviral activity against Nipah virus proteins.
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