A reanalysis of SARS-CoV-2 deep sequencing data from donor-recipient pairs indicates that transmission bottlenecks are very narrow (one to three virions).
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301528 | PMC |
http://dx.doi.org/10.1126/scitranslmed.abh1803 | DOI Listing |
Mamm Genome
January 2025
Phenomics Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Research infrastructure is critical for advancing knowledge of health and disease, fostering innovation through world-class, cutting-edge facilities and technical expertise. Phenomics Australia is Australia's national research infrastructure provider responsible for accelerating advances in mammalian functional genomics and precision medicine through the development and delivery of services and expertise in engineered disease model production, phenotyping, and biobanking. These capabilities and resources are enabled by Australia's National Collaborative Research Infrastructure Strategy and primarily support health and medical research for significant healthcare and economic benefits.
View Article and Find Full Text PDFTransl Lung Cancer Res
December 2024
Department of Medicine II, Hematology and Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
Dig Liver Dis
January 2025
Department of Biology, University of Pisa, Via Luca Ghini, 13, 56126, Pisa, Italy. Electronic address:
Mol Cell
January 2025
Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. Electronic address:
By building synthetic regulatory landscapes, Jensen et al. and Thomas et al. demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.
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