Objectives/hypothesis: Adenotonsillectomy (AT) is generally considered the first line treatment for pediatric patients with obstructive sleep apnea (OSA). Pediatric patients with severe OSA have worse outcomes after AT than patients with milder OSA. It is currently unclear if this group of higher morbidity patients should be subdivided further. This study investigates patients with severe pediatric OSA to determine if there are differences in postsurgical outcomes based on initial severity of sleep disordered breathing, medical comorbidities, or demographic factors.

Study Design: Retrospective cohort study at a single tertiary referral center.

Methods: Patients aged 2-18 who underwent polysomnogram (PSG) from October 2012 to January 2019, had an apnea-hypopnea index (AHI) >10, and subsequently underwent AT were identified using a filter through electronic medical record. A total of 112 patients underwent both pre- and postoperative PSG. Bivariate analysis was conducted via Pearson chi-square test. Univariate and multivariate analyses via binary logistic and multinomial linear regressions were performed using SPSS.

Results: Of the 112 patients included in this study, 68 patients were identified as having severe OSA (AHI = 10-20) and 44 as having very severe OSA (AHI > 20). Very severe OSA patients were significantly less likely to be cured of sleep disordered breathing or have their OSA reduced to mild OSA. Obese patients were found to have less reduction in AHI after AT.

Conclusions: The postsurgical outcomes of patients with severe and very severe OSA are significantly different indicating that patients traditionally categorized as having severe OSA may need to be further subcategorized.

Level Of Evidence: 4 Laryngoscope, 132:1855-1860, 2022.

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.29916DOI Listing

Publication Analysis

Top Keywords

severe osa
24
patients
13
patients severe
12
osa
11
severe
10
severe pediatric
8
obstructive sleep
8
sleep apnea
8
pediatric patients
8
outcomes patients
8

Similar Publications

Objective: The apnea-hypopnea index (AHI) defines obstructive sleep apnea (OSA) severity but fails to describe nuances in disease burden. The modified sleep apnea severity index (mSASI) combines patient anatomy, weight, sleep study metrics, and symptoms to provide a composite OSA index ranging from 1 to 3. While prior studies have associated mSASI with quality of life and hypertension, its utility in continuous positive pressure intolerant (CPAPi) surgical patients remains unexplored.

View Article and Find Full Text PDF

Obstructive Sleep Apnea Syndrome: Prediction of Lipid Panel in Relation to Apnea- Hypopnea Index.

Indian J Otolaryngol Head Neck Surg

January 2025

Otorhinolaryngology Department, Faculty of Medicine, Benha University, Benha, 13511 Qalyubia Egypt.

The research was designed to predict the relationship between the apnea-hypopnea index (AHI) as the main indicator of severity of obstructive sleep apnea syndrome (OSAS), and lipid panel test results. A cross-sectional observational study was done on 90 patients with suspected sleep-related breathing disorders as assumed by polysomnography. Patients were categorized into three equal groups depending on AHI: mild degree (5-15 events/hour), moderate degree (15-30 events/hour), and severe degree (> 30 events/hour).

View Article and Find Full Text PDF

Insomnia features and patient-reported daytime sleepiness in patients with obstructive sleep apnea.

Sleep Med

February 2025

Department of Sports Medicine, Rehabilitation and Disease Prevention, University of Mainz, Mainz, Germany.

Previous preliminary evidence suggests insomnia features playing a major causative or confounding role in daytime sleepiness in obstructive sleep apnea (OSA) patients. We investigated further this hypothesis in a larger OSA patient cohort. In a cross-sectional study in a tertiary medical center, consecutive patients presenting with suspected OSA, but without other sleepiness-promoting comorbidities, and tested by in-lab polysomnography (PSG) were evaluated prospectively for excessive daytime sleepiness (EDS) using the Epworth Sleepiness Scale (ESS) and for insomnia using the Insomnia Severity Index (ISI) respectively.

View Article and Find Full Text PDF

Objective: Obstructive Sleep Apnea (OSA) is a common heterogeneous sleep disorder that significantly impacts the sleep quality of individuals and leads to severe complications. Patients with OSA often experience disrupted circadian rhythm, hyperactive hypoxia response, and endothelial dysfunction, yet the underlying molecular mechanism remains poorly known. Recent research suggests promising evidence of the potential role of SIRT1 in the etiology of OSA, warranting further investigation.

View Article and Find Full Text PDF

Background: Obstructive sleep apnea (OSA) is a prevalent and potentially severe sleep disorder characterized by repeated interruptions in breathing during sleep. Machine learning models have been increasingly applied in various aspects of OSA research, including diagnosis, treatment optimization, and developing biomarkers for endotypes and disease mechanisms.

Methods: This narrative review examines data extracted from 254 scientific publications published between 2018 and 2023 across a wide spectrum of research efforts, from diagnostic algorithms to treatment and patient management strategies.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!