AI Article Synopsis
- The report discusses a multicenter, randomized controlled trial aimed at determining if targeted antimicrobial prophylaxis, based on rectal culture screening, can prevent acute bacterial prostatitis after transrectal prostate biopsy (TRPB).
- Patients in the trial will be split into two groups: one receiving tailored antibiotics like tazobactam-piperacillin or levofloxacin, and the other receiving standard levofloxacin treatment.
- The study's main goal is to measure the rate of acute bacterial prostatitis occurrences post-biopsy, with recruitment for the trial starting in April 2021 and a target of 5,100 participants.
Article Abstract
The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.
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| http://dx.doi.org/10.18926/AMO/62782 | DOI Listing |
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