Immediate and delayed effects of cis-platinum treatment on the short term biodistribution of 67Ga-citrate in mice.

The co-administration of a single medium toxic dose (5 mg/kg) of the chemotherapeutic drug cis-platinum (cis-Pt) with 67Ga-citrate was found to have minimal effects on the 3 h tissue distribution of the radiopharmaceutical in mice. When the same drug dose was given at two day intervals preceding the co-administered dose, virtually all tissues accumulated 67Ga to a greater extent. The tissue distribution of radiolabeled cis-Pt supported the development of drug-induced renal dysfunction as the primary cause.