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http://dx.doi.org/10.1186/s12995-021-00340-0 | DOI Listing |
Epilepsia
December 2024
Department of Neuroscience and Medical Genetics, Children's Hospital Meyer IRCCS, Florence, Italy.
Objective: Fenfluramine (FFA), stiripentol (STP), and cannabidiol (CBD) are approved add-on therapies for seizures in Dravet syndrome (DS). We report on the long-term safety and health care resource utilization (HCRU) of patients with DS treated with FFA under an expanded access program (EAP).
Methods: A cohort of 124 patients received FFA for a median of 2.
Surg Radiol Anat
December 2024
Department of Anatomy, Digital Imaging and 3D Modelling Laboratory, Faculty of Medicine, Ege University, Bornova, 35100, Izmir, Turkey.
Purpose: The challenges of spinal surgery can be overcome by deeply understanding the anatomical and surgical complexities of the region through the use of model simulators. This study investigates the impact of digitally designed simulators, specifically lumbar spinal models with abnormal curvature, on preoperative planning and their effectiveness as training tools. The study addresses challenges in spine surgery, such as unique deformities, classification issues, and associated abdominal structure abnormalities.
View Article and Find Full Text PDFCrit Care
December 2024
Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Background: Entropy quantifies the level of disorder within a system. Low entropy reflects increased rigidity of homeostatic feedback systems possibly reflecting failure of protective physiological mechanisms like cerebral autoregulation. In traumatic brain injury (TBI), low entropy of heart rate and intracranial pressure (ICP) predict unfavorable outcome.
View Article and Find Full Text PDFOphthalmology
December 2024
Department of Ophthalmology, Stanford University, Palo Alto, CA.
Objective: Achieving near normal vision following unilateral congenital cataract surgery is possible but requires early surgery, optical correction and consistent patching. Patching is often challenging for children and their caregivers. The goal of these analyses is to examine the association between reported consistency in patching during the first year after surgery and visual acuity.
View Article and Find Full Text PDFIran J Parasitol
January 2024
Department of Internal Medicine, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
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