Training certifiable neural networks enables us to obtain models with robustness guarantees against adversarial attacks. In this work, we introduce a framework to obtain a provable adversarial-free region in the neighborhood of the input data by a polyhedral envelope, which yields more fine-grained certified robustness than existing methods. We further introduce polyhedral envelope regularization (PER) to encourage larger adversarial-free regions and thus improve the provable robustness of the models. We demonstrate the flexibility and effectiveness of our framework on standard benchmarks; it applies to networks of different architectures and with general activation functions. Compared with state of the art, PER has negligible computational overhead; it achieves better robustness guarantees and accuracy on the clean data in various settings.
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http://dx.doi.org/10.1109/TNNLS.2021.3111892 | DOI Listing |
bioRxiv
October 2024
Los Alamos National Laboratory, Bioscience Division, Microbial and Biome Sciences group, Los Alamos, NM, USA.
Carboxysomes are polyhedral protein organelles that microorganisms use to facilitate carbon dioxide assimilation. They are composed of a modular protein shell which envelops an enzymatic core mainly comprised of physically coupled Rubisco and carbonic anhydrase. While the modular construction principles of carboxysomes make them attractive targets as customizable metabolic platforms, their size and complexity can be a hinderance.
View Article and Find Full Text PDFNature
March 2024
Department of Biochemistry, University of Washington, Seattle, WA, USA.
ACS Appl Mater Interfaces
January 2023
Institute of Bioengineering and Bioimaging, A*STAR, 31 Biopolis Way, Singapore 138669.
Supramolecules have been drawing increasing attention recently in addressing healthcare challenges caused by infectious pathogens. We herein report a novel class of guanidinium-perfunctionalized polyhedral oligomeric silsesquioxane (Gua-POSS) supramolecules with highly potent antimicrobial activities. The modular structure of Gua-POSS consists of an inorganic T10 or T8 core ( = 10 or 8), flexible linear linkers of varying lengths ( = 1 or 3), and peripherally aligned cationic guanidinium groups as the membrane-binding units.
View Article and Find Full Text PDFViruses
December 2021
State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University, Yangling, Xianyang 712100, China.
The larch looper, Staudinger (Lepidoptera: Geometridae), is one of the major insect pests of larch forests, widely distributed from southeastern Europe to East Asia. A naturally occurring baculovirus, Erannis ankeraria nucleopolyhedrovirus (EranNPV), was isolated from larvae. This virus was characterized by electron microscopy and by sequencing the whole viral genome.
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