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Role of senescence in the chronic health consequences of COVID-19. | LitMetric

Role of senescence in the chronic health consequences of COVID-19.

Transl Res

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Division of Geriatrics and Gerontology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Published: March 2022

AI Article Synopsis

  • Early studies suggest that about 10% of COVID-19 patients develop Long-Hauler's Syndrome, experiencing persistent symptoms for more than three weeks.
  • Older adults are more susceptible to severe COVID-19 outcomes, and age-related factors, like cellular aging and inflammation, may worsen their risk of long-term effects.
  • Research into senolytics and geroscience treatments could potentially help delay or reduce Long-Hauler's Syndrome by addressing underlying aging processes.

Article Abstract

While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long-Hauler's Syndrome or PACS (postacute sequelae of SARS-CoV-2 infection). There is little known about risk factors or predictors of susceptibility for Long-Hauler's Syndrome, but older adults are at greater risk for severe outcomes and mortality from COVID-19. The pillars of aging (including cellular senescence, telomere dysfunction, impaired proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, genomic instability, progenitor cell exhaustion, altered intercellular communication, and epigenetic alterations) that contribute to age-related dysfunction and chronic diseases (the "Geroscience Hypothesis") may interfere with defenses against viral infection and consequences of these infections. Heightening of the low-grade inflammation that is associated with aging may generate an exaggerated response to an acute COVID-19 infection. Innate immune system dysfunction that leads to decreased senescent cell removal and/or increased senescent cell formation could contribute to accumulation of senescent cells with both aging and viral infections. These processes may contribute to increased risk for long-term COVID-19 sequelae in older or chronically ill patients. Hence, senolytics and other geroscience interventions that may prolong healthspan and alleviate chronic diseases and multimorbidity linked to fundamental aging processes might be an option for delaying, preventing, or alleviating Long-Hauler's Syndrome.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532377PMC
http://dx.doi.org/10.1016/j.trsl.2021.10.003DOI Listing

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