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Investigating acoustic startle habituation and prepulse inhibition with silent functional MRI and electromyography in young, healthy adults.
Front Hum Neurosci
August 2024
Centre for Cognitive and Clinical Neuroscience, College of Health, Medicine and Life Sciences, Brunel University London, London, United Kingdom.
Article Synopsis
- The study explores how human neural mechanisms involved in startle habituation and prepulse inhibition (PPI) work, utilizing silent fMRI to bypass auditory noise complications.
- Results indicated that as participants adapted to startling stimuli, their responses decreased, with notable changes in brain activity in regions like the thalamus and insula.
- Overall, while startle habituation showed clear neural correlates, PPI demonstrated minimal effective results in terms of neural activity.
BOLD asynchrony: An imaging biomarker of tumor burden in IDH-mutated gliomas.
Neuro Oncol
January 2022
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
BOLD asynchrony elucidates tumor burden in IDH-mutated gliomas.
Neuro Oncol
January 2022
Department of Radiology, Columbia University, New York, New York, USA.
Background: Gliomas comprise the most common type of primary brain tumor, are highly invasive, and often fatal. IDH-mutated gliomas are particularly challenging to image and there is currently no clinically accepted method for identifying the extent of tumor burden in these neoplasms. This uncertainty poses a challenge to clinicians who must balance the need to treat the tumor while sparing healthy brain from iatrogenic damage.
View Article and Find Full Text PDFTrunk rotation and handedness modulate cortical activation in neglect-associated regions during temporal order judgments.
Neuroimage Clin
June 2020
Department of Cognitive Neurology, University Medicine Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany; DFG Center for Nanoscale Microscopy & Molecular Physiology of the Brain (CNMPB), Germany; German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Göttingen 37077, Germany; Leibniz-science campus primate cognition, Germany.
The rotation of the trunk around its vertical midline could be shown to bias visuospatial temporal judgments towards targets in the hemifield ipsilateral to the trunk orientation and to improve visuospatial performance in patients with visual neglect. However, the underlying brain mechanisms are not well understood. Therefore, the goal of the present study was to investigate the neural effects associated with egocentric midplane shifts under consideration of individual handedness.
View Article and Find Full Text PDFOverlapping but Divergent Neural Correlates Underpinning Audiovisual Synchrony and Temporal Order Judgments.
Front Hum Neurosci
July 2018
School of Psychology, University of Glasgow, Glasgow, United Kingdom.
Multisensory processing is a core perceptual capability, and the need to understand its neural bases provides a fundamental problem in the study of brain function. Both synchrony and temporal order judgments are commonly used to investigate synchrony perception between different sensory cues and multisensory perception in general. However, extensive behavioral evidence indicates that these tasks do not measure identical perceptual processes.
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