[This corrects the article DOI: 10.1371/journal.pcbi.1008550.].
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http://dx.doi.org/10.1371/journal.pcbi.1009551 | DOI Listing |
It is well known that activation of NMDA receptors can trigger long-term synaptic depression (LTD) and that a morphological correlate of this functional plasticity is spine retraction and elimination. Recent studies have led to the surprising conclusion that NMDA-induced spine shrinkage proceeds independently of ion flux and requires the initiation of protein synthesis, highlighting an unappreciated contribution of mRNA translation to non-ionotropic NMDAR signaling. Here we used NMDA-induced spine shrinkage in slices of mouse hippocampus as a readout to investigate this novel modality of synaptic transmission.
View Article and Find Full Text PDFEchocardiography
January 2025
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Objectives: Numerous studies have demonstrated impaired right ventricular (RV) synchronicity in pulmonary arterial hypertension (PAH). However, few studies have focused on connective tissue disease (CTD)-associated PAH. This study evaluates RV dyssynchrony and its prognostic value in CTD-associated PAH.
View Article and Find Full Text PDFJ Prosthodont
December 2024
Advanced Graduate Prosthodontics, Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Purpose: Optical tracking devices (OTDs) hold promise for enhancing patient-centered prostheses, but their efficacy remains underexplored. This clinical study aimed to comprehensively evaluate differences in static and dynamic occlusions among occlusal appliances fabricated using optical tracking, conventional tracking, and average articulator values (AAVs), providing insights into their efficacy in clinical and research-based practices.
Materials And Methods: Twelve dentate participants aged over 25 years, with Angle Class I and II occlusal relationships, were enrolled.
ACS Chem Biol
November 2024
RA Capital Ventures, Boston, Massachusetts 02116, United States.
Mutations in creatine transporter SLC6A8 cause creatine transporter deficiency (CTD), which is responsible for 2% of all cases of X-linked intellectual disability. CTD has no current treatments and has a high unmet medical need. Inspired by the transformational therapeutic impact of small molecule "correctors" for the treatment of cystic fibrosis, which bind to mutated versions of the CFTR ion channel to promote its trafficking to the cell surface, we sought to identify small molecules that could stabilize SLC6A8 as a potential treatment for CTD.
View Article and Find Full Text PDFIndian J Dent Res
April 2024
Biochemistry Research Laboratory, Omsk State Pedagogical University, Omsk, Russia.
Aims: This study aimed to investigate the rate and quality of maturation of the mineral component of impacted teeth 38 and 48 and a fragment of the human lower jaw with connective tissue dysplasia (CTD) in different periods of postnatal ontogenesis.
Methods And Material: The study involved 102 males (76 with CTD and 26 without CTD), divided into age groups: 31-40, 41-50 and 51-60 years. For medical reasons, teeth 38 and 48 were removed from each patient, as well as a fragment of the alveolar part of the lower jaw in the projection of teeth 38 and 48 measuring 0.
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