Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530409 | PMC |
| http://dx.doi.org/10.1038/s43018-020-00127-y | DOI Listing |
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