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Aortic Valve Plasty for Coexistence of Discrete Subvalvular Aortic Stenosis and Quadricuspid Aortic Valve: A Case Report.
Cureus
December 2024
Cardiovascular Surgery, Ayase Heart Hospital, Tokyo, JPN.
Subvalvular aortic stenosis typically manifests at a young age and rarely presents in adulthood. It may cause left ventricular outflow tract stenosis, which requires surgical treatment in severe cases. The coexistence of discrete subvalvular aortic stenosis and quadricuspid aortic valve is a highly unusual finding.
View Article and Find Full Text PDF[Long-term postoperative outcomes after surgical correction of congenital subaortic stenosis].
Khirurgiia (Mosk)
December 2024
Penza State University, Penza, Russia.
Objective: To analyze the results of surgical treatment of discrete subaortic stenosis and identify the main factors of left ventricular outflow tract (LVOT) restenosis in long-term postoperative period.
Material And Methods: There were 87 surgical interventions in 63 patients with congenital subaortic stenosis between 2008 and 2023. Mean preoperative peak systolic LVOT pressure gradient was 72 mmHg (50-110 mmHg).
Contemporary Clinical Characteristics, Imaging, Management, and Surgical and Nonsurgical Outcomes of Adult Patients With Subaortic Stenosis.
J Am Heart Assoc
November 2024
Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.
Article Synopsis
- Subaortic stenosis (SAS) is a condition in adults where a fibromuscular membrane obstructs blood flow below the aortic valve, potentially leading to serious heart complications.
- A study of 484 patients between 2011 and 2022 showed that over a median follow-up of 5.5 years, 11.5% died, and 6.8% were hospitalized for heart failure, with notable recurrence of SAS in 8.0% of cases.
- Key factors impacting mortality and disease recurrence included older age and baseline heart function, highlighting the need for more research to improve treatment strategies.
Development of Novel 3D Spheroids for Discrete Subaortic Stenosis.
Cardiovasc Eng Technol
December 2024
Laboratory for Regenerative Tissue Repair, Texas Children's Hospital, Houston, TX, USA.
In this study, we propose a new method for bioprinting 3D Spheroids to study complex congenital heart disease known as discrete subaortic stenosis (DSS). The bioprinter allows us to manipulate the extrusion pressure to change the size of the spheroids, and the alginate porosity increases in size over time. The spheroids are composed of human umbilical vein endothelial cells (HUVECs), and we demonstrated that pressure and time during the bioprinting process can modulate the diameter of the spheroids.
View Article and Find Full Text PDFStorytelling of Hypertrophic Cardiomyopathy Discovery.
J Cardiovasc Dev Dis
September 2024
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, 35121 Padova, Italy.
Article Synopsis
- The discovery of hypertrophic cardiomyopathy (HCM) began in 1958 when Donald Teare noted cases of asymmetric ventricular septum hypertrophy during autopsies, linking sudden deaths to this condition.
- The term "idiopathic hypertrophic subaortic stenosis" emerged in the late 1950s and highlighted the confusion between HCM and valve-related issues, as seen in cases managed by Eugene Braunwald and Andrew Glenn Morrow.
- Over the decades, HCM has been classified and better understood, evolving from early notions of "functional subaortic stenosis" to a formal classification of cardiomyopathies established by John F. Goodwin and refined by the WHO, recognizing familial links and new types
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