AI Article Synopsis
- Physiological circadian rhythms are essential for maintaining bone health, and disruptions in these rhythms can lead to issues like osteoporosis.
- Research in animals shows that genes related to the body's internal clock have significant effects on bone structure and quality, and similar patterns are observed in humans.
- This review highlights current findings on how bone remodeling follows a circadian pattern, identifies gaps in understanding, and suggests new treatment approaches based on this knowledge to combat osteoporosis.
Article Abstract
Physiological circadian (ie, 24-hour) rhythms are critical for bone health. Animal studies have shown that genes involved in the intrinsic molecular clock demonstrate potent circadian expression patterns in bone and that genetic disruption of these clock genes results in a disturbed bone structure and quality. More importantly, circulating markers of bone remodeling show diurnal variation in mice as well as humans, and circadian disruption by, eg, working night shifts is associated with the bone remodeling disorder osteoporosis. In this review, we provide an overview of the current literature on rhythmic bone remodeling and its underlying mechanisms and identify critical knowledge gaps. In addition, we discuss novel (chrono)therapeutic strategies to reduce osteoporosis by utilizing our knowledge on circadian regulation of bone. © 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520066 | PMC |
| http://dx.doi.org/10.1002/jbm4.10504 | DOI Listing |
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