Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526732 | PMC |
| http://dx.doi.org/10.3389/fmed.2021.745838 | DOI Listing |
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