In network science, the non-homogeneity of node degrees has been a concerning issue for study. Yet, with today's modern web technologies, the traditional social communication topologies have evolved from node-central structures into online cycle-based communities, urgently requiring new network theories and tools. Switching the focus from node degrees to network cycles could reveal many interesting properties from the perspective of totally homogenous networks or sub-networks in a complex network, especially basic simplexes (cliques) such as links and triangles. Clearly, compared with node degrees, it is much more challenging to deal with network cycles. For studying the latter, a new clique vector-space framework is introduced in this paper, where the vector space with a basis consisting of links has a dimension equal to the number of links, that with a basis consisting of triangles has the dimension equal to the number of triangles and so on. These two vector spaces are related through a boundary operator, for example mapping the boundary of a triangle in one space to the sum of three links in the other space. Under the new framework, some important concepts and methodologies from algebraic topology, such as characteristic number, homology group and Betti number, will play a part in network science leading to foreseeable new research directions. As immediate applications, the paper illustrates some important characteristics affecting the collective behaviors of complex networks, some new cycle-dependent importance indexes of nodes and implications for network synchronization and brain-network analysis.
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http://dx.doi.org/10.1093/nsr/nwz050 | DOI Listing |
Indian J Clin Biochem
January 2025
Department of Clinical Biochemistry, SKIMS, Srinagar, India.
The increasing incidence of gastric cancer (GC) in the Kashmir Valley is concerning, but its root causes are largely unknown. Dysregulated activation of the Hedgehog signaling pathway has been linked to various cancers, and the Human Hedgehog Interacting Protein (HHIP), a tumor suppressor, is frequently dysregulated in malignancies. However, the expression of the HHIP gene in GC is inconsistent and poorly understood.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Pulmonary and Critical Care Medicine II, Emergency General Hospital, Beijing, China.
Existing studies indicate that dysregulation or abnormal expression of small nucleolar RNA (snoRNA) is closely associated with various diseases, including lung cancer. Furthermore, these diseases often involve multiple targets, making the redevelopment of traditional medicines highly promising. Accurate prediction of potential snoRNA therapeutic targets is essential for early disease intervention and the redevelopment of traditional medicines.
View Article and Find Full Text PDFZhonghua Zhong Liu Za Zhi
January 2025
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China.
To explore the clinicopathological features of rectal neuroendocrine tumor (R-NET) G2, identify prognostic factors, and summarize treatment experience. The clinical data of patients diagnosed with R-NET G2 by pathological diagnosis admitted to Cancer Hospital of the Chinese Academy of Medical Sciences from January 2003 to September 2023 were retrospectively analyzed. The Fisher's exact test and Kaplan-Meier curves were performed to analyze the association between pathological features and prognosis.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, China.
To investigate the presence of modular loss of coupling and abnormal alterations in functional and structural networks in the brain networks of patients with postherpetic neuralgia (PHN). We collected resting-state functional magnetic resonance imaging data and diffusion tensor imaging data from 82 healthy controls (HCs) and 71 PHN patients, generated structural connectivity (SC) and functional connectivity (FC) networks, and assessed the corresponding clinical information assessment. Based on AAL(90) mapping, the brain network was divided into 9 modules, and the structural-functional connectivity (SC-FC) coupling was compared at the whole-brain level and within the modules, as well as alterations in the topological properties of the brain network in the patient group.
View Article and Find Full Text PDFNeuropsychologia
January 2025
Queensland Brain Institute, The University of Queensland; School of Psychology, The University of Queensland; CIFAR, Canada.
Endogenous visuo-spatial attention is under the control of a fronto-parietal network of brain regions. One key node in this network, the intra-parietal sulcus (IPS), plays a crucial role in maintaining endogenous attention, but little is known about its ongoing physiology and network dynamics during different attentional states. Here, we investigated the reactivity of the left IPS in response to brain stimulation under different states of selective attention.
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