Mingjie Zhang is a distinguished structural biologist whose research interest is the protein assemblies in cells, particularly those at the synapse, where two neurons meet and transmit nervous impulses from one to the other. In recent years, his group discovered the phenomenon of phase separation in both the pre- and post-synaptic sites of neurons and elucidated its regulation and physiological function. In this interview, Executive Editor-in-Chief Mu-ming Poo talks with Prof. Zhang on the fast-developing research area of biological phase separation, as well as Zhang's new role as the Founding Dean of the School of Life Sciences at Southern University of Science and Technology (SUSTech) in Shenzhen.
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http://dx.doi.org/10.1093/nsr/nwab081 | DOI Listing |
Adv Sci (Weinh)
January 2025
School of Public Health, Capital Medical University, Beijing, 100069, P. R. China.
Substantial epidemiological evidence suggests a significant correlation between particulate matter 2.5 (PM) and lung cancer. However, the mechanism underlying this association needs to be further elucidated.
View Article and Find Full Text PDFAm J Transl Res
December 2024
Department of Pharmacy, The Fourth Hospital of Hebei Medical University Shijiazhuang 050000, Hebei, China.
Objectives: The aim of this study was to establish an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the detection of osimertinib in rat plasma, lung and brain tissues.
Methods: Forty-eight rats were randomly divided into an experimental group (receiving osimertinib at doses of 5, 8, and 10 mg/kg) and a control group. After continuous intragastric administration for 15 days, samples of blood, lung, and brain tissue were collected.
Endocrinol Diabetes Metab J
June 2024
Medical & Research Services, Veterans Affairs New Jersey Healthcare System, East Orange, New Jersey, USA.
Aims: Behavioral pattern separation is a hippocampal-dependent component of episodic memory and a sensitive marker of early cognitive decline. Here we tested whether mild traumatic injury causes loss of pattern separation in the rat and for its prevention by a novel neuroprotective peptide fragment of the human serotonin 2A receptor (SN..
View Article and Find Full Text PDFSmall
January 2025
Dept. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Transient amorphous phases are known as functional precursors in the formation of crystalline materials, both in vivo and in vitro. A common route to regulate amorphous calcium carbonate (ACC) crystallization is via direct interactions with negatively charged macromolecules. However, a less explored phenomenon that can influence such systems is the electrostatically driven formation of Ca-macromolecule dense phases.
View Article and Find Full Text PDFAdv Mater
January 2025
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
Ionic conductive hydrogels have emerged as an excellent option for constructing dielectric layers of interfacial iontronic sensors. Among these, gradient ionic hydrogels, due to the intrinsic gradient elastic modulus, can achieve a wide range of pressure responses. However, the fabrication of gradient hydrogels with optimal mechanical and sensing properties remains a challenge.
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