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Background: The prevalence of atopic dermatitis (AD) is increasing worldwide. Prenatal particulate matter with an aerodynamic diameter <2.5 μm (PM) and maternal anxiety during pregnancy has been suggested as a potential causes of AD. This study investigated the effects of prenatal PM and maternal anxiety on AD and identified the critical period of PM exposure for AD in infants.
Methods: This study included 802 children from the COCOA birth cohort study with follow-up data at 1 year of age. PM was estimated by land-use regression models and prenatal anxiety was measured with a questionnaire. AD was diagnosed by doctor at 1 year of age. Logistic regression analysis and Bayesian distributed lag interaction models were applied.
Results: Higher PM during the first trimester of pregnancy, higher prenatal maternal anxiety, and male gender were associated with AD at 1 year of age (adjusted odds ratio [aOR] and 95% confidence interval [CI]: 1.86 [1.08-3.19], 1.58 [1.01-2.47], and 1.54 [1.01-2.36], respectively). Higher PM during the first trimester and higher maternal anxiety during pregnancy showed an additive effect on the risk of AD (aOR: 3.13; 95% CI: 1.56-6.28). Among boys exposed to higher maternal anxiety during pregnancy, gestational weeks 5-8 were the critical period of PM exposure for the development of AD.
Conclusions: Higher PM exposure during gestational weeks 5-8 increased the probability of AD in infancy, especially in boys with higher maternal anxiety. Avoiding PM exposure and maternal anxiety from the first trimester may prevent infant AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519998 | PMC |
| http://dx.doi.org/10.1002/clt2.12070 | DOI Listing |
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