AI Article Synopsis
- Osteoporosis and its complications are believed to stem from bone aging, environmental influences, and genetic factors, with oxidative stress playing a critical role in age-related bone issues.
- This study analyzed genetic variants related to oxidative stress in 221 patients with osteoporosis and 354 controls over a 12-14 year period.
- Key findings indicated that the SNP rs4077561 in the TXNRD1 gene significantly increases fracture risk, alongside other SNPs in related genes like M6PR and GPX6, highlighting the importance of genetic predisposition in osteoporosis.
Article Abstract
The most widely accepted etiopathogenesis hypothesis of the origin of osteoporosis and its complications is that they are a consequence of bone aging and other environmental factors, together with a genetic predisposition. Evidence suggests that oxidative stress is crucial in bone pathologies associated with aging. The aim of this study was to determine whether genetic variants in oxidative stress-related genes modified the risk of osteoporotic fracture. We analysed 221 patients and 354 controls from the HORTEGA sample after 12-14 years of follow up. We studied the genotypic and allelic distribution of 53 SNPs in 24 genes involved in oxidative stress. The results showed that being a carrier of the variant allele of the SNP rs4077561 within TXNRD1 was the principal genetic risk factor associated with osteoporotic fracture and that variant allele of the rs1805754 M6PR, rs4964779 TXNRD1, rs406113 GPX6, rs2281082 TXN2 and rs974334 GPX6 polymorphisms are important genetic risk factors for fracture. This study provides information on the genetic factors associated with oxidative stress which are involved in the risk of osteoporotic fracture and reinforces the hypothesis that genetic factors are crucial in the etiopathogenesis of osteoporosis and its complications.
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| http://dx.doi.org/10.1016/j.gene.2021.146036 | DOI Listing |
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