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Phylogeny-based comparative analysis of gene expression modulation upon drought stress across three cotton diploids.
BMC Plant Biol
January 2025
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Background: Drought stress is a significant global challenge that negatively impacts cotton fiber yield and quality. Although many drought-stress responsive genes have been identified in cotton species (Gossypium spp.), the diversity of drought response mechanisms across cotton species remains largely unexplored.
View Article and Find Full Text PDFKLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis.
Commun Biol
January 2025
Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage and surrounding tissues. The transcription factor Kruppel-like family factor 9 (KLF9) has been identified as a regulator of tumorigenesis. However, its role in OA is still not fully understood.
View Article and Find Full Text PDFAstemizole Exacerbates 5-Fluorouracil-Triggered Cardiotoxicity by Enhancing Ptgs2.
Cardiovasc Toxicol
January 2025
Department of Cardiology, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, China.
5-fluorouracil (5-FU), a commonly utilized antitumor agent for the treatment of colon cancer, is linked to an increased risk of cardiovascular diseases. Antihistamines including astemizole (AST) have been reported to present cardiovascular toxicity; however, it remains unclear how 5-FU-mediated cardiotoxicity is affected by AST during the treatment of colon cancer. This study explored the role of AST in 5-FU-induced cardiotoxicity in colon cancer.
View Article and Find Full Text PDFBlunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis.
Schizophr Bull
January 2025
Department of Psychology, University of Maryland, College Park, MD 20742, United States.
Background And Hypothesis: Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a central role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences.
View Article and Find Full Text PDF[Paternal inheritance mediated by epigenetic changes in sperms].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Epigenetics is the link between the genome and environment, which can respond to physiological (such as age) or environmental factors (such as diet, stress, and pollution) and induce changes in epigenetic modifications (such as DNA methylation, non-coding RNA, and histone modifications). It can also serve as cellular memory transmitted from generation to generation. Sperm is highly responsive to such environmental changes and has unique epigenetic profiles.
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