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http://dx.doi.org/10.1002/ueg2.12168 | DOI Listing |
Microbiome
January 2025
Department of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.
Background: The human gut microbiome strongly influences host metabolism by fermenting dietary components into metabolites that signal to the host. Our previous work has shown that Intestinimonas butyriciproducens is a prevalent commensal bacterium with the unique ability to convert dietary fructoselysine to butyrate, a well-known signaling molecule with proven health benefits. Dietary fructoselysine is an abundant Amadori product formed in foods during thermal treatment and is part of foods rich in dietary advanced glycation end products which have been associated with cardiometabolic disease.
View Article and Find Full Text PDFIndian J Gastroenterol
January 2025
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
Clostridioides difficile (C. difficile) infection (CDI) is common after antibiotic exposure and presents significant morbidity, mortality and healthcare costs worldwide. The rising incidence of recurrent CDI, driven by hypervirulent strains, widespread antibiotic use and increased community transmission, has led to an urgent need for novel therapeutic strategies.
View Article and Find Full Text PDFChemistry
January 2025
Departamento de Química Inorgánica, -, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Zaragoza - CSIC, 50009, Zaragoza, Spain.
Hexahydride OsH(PPr) (1) releases H to form the isomeric tetrahydrides 2 a and 2 b of general formula OsH(PPr). Tetrylenes E{N(SiMe)} (E=Ge, Sn) are able to selectively trap these isomers distinguishing between them. Tetrylene Ge{N(SiMe)} catches 2 b to generate OsH{Ge[N(SiMe)]}(PPr) (3), which has a piano stool geometry, while Sn{N(SiMe)} captures 2 a to give OsH{Sn[N(SiMe)]}(PPr) (4) with the donor atoms defining a pentagonal bipyramid around the osmium center.
View Article and Find Full Text PDFGut Microbes
December 2025
Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA.
To study the impact of differing specific pathogen-free gut microbiomes (GMs) on a murine model of inflammatory bowel disease, selected GMs were transferred using embryo transfer (ET), cross-fostering (CF), and co-housing (CH). Prior work showed that the GM transfer method and the microbial composition of donor and recipient GMs can influence microbial colonization and disease phenotypes in dextran sodium sulfate-induced colitis. When a low richness GM was transferred to a recipient with a high richness GM via CH, the donor GM failed to successfully colonize, and a more severe disease phenotype resulted when compared to ET or CF, where colonization was successful.
View Article and Find Full Text PDFPlant Foods Hum Nutr
January 2025
Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Col. San Isidro, Km 8.5 Carr. Yautepec-Jojutla, Yautepec, Morelos, C.P. 62731, México.
The relationship between the gut microbiota (GM) and the health of human beings has been a topic of growing interest in the last few years. Legumes are a rich source of indigestible carbohydrates, including resistant starch (RS), which are substrates of the GM. The aim of this study was to evaluate the effect of the indigestible fraction of legumes on the fecal microbiota of normal-weight (NW) and obese (O) donors.
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