AI Article Synopsis
- There is a need for effective biomarkers to monitor EEG activity and seizure risk in patients with acute brain injuries, as seizures can lead to further neurological issues.
- The study involved 11 patients with refractory status epilepticus, tracking their serum levels of neuron-specific enolase (NSE) and S100-beta alongside EEG activity over several days.
- Results showed that NSE levels correlated with EEG scores and could predict seizure recurrence, with levels above 17 ng/ml indicating a 71% seizure occurrence and a rise of more than 15% predicting recurrence in 80% of patients.
Article Abstract
Background And Purpose: There is a need for accurate biomarkers to monitor electroencephalography (EEG) activity and assess seizure risk in patients with acute brain injury. Seizure recurrence may lead to cellular alterations and subsequent neurological sequelae. Whether neuron-specific enolase (NSE) and S100-beta (S100B), brain injury biomarkers, can reflect EEG activity and help to evaluate the seizure risk was investigated.
Methods: Eleven patients, admitted to an intensive care unit for refractory status epilepticus, who underwent a minimum of 3 days of continuous EEG concomitantly with daily serum NSE and S100B assays were included. At 103 days the relationships between serum NSE and S100B levels and two EEG scores able to monitor the seizure risk were investigated. Biochemical biomarker thresholds able to predict seizure recurrence were sought.
Results: Only NSE levels positively correlated with EEG scores. Similar temporal dynamics were observed for the time courses of EEG scores and NSE levels. NSE levels above 17 ng/ml were associated with seizure in 71% of patients. An increase of more than 15% of NSE levels was associated with seizure recurrence in 80% of patients.
Conclusions: Our study highlights the potential of NSE as a biomarker of EEG activity and to assess the risk of seizure recurrence.
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| http://dx.doi.org/10.1111/ene.15154 | DOI Listing |
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