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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525321 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2021.109778 | DOI Listing |
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Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome.
Cell Rep
August 2021
Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Beijing, China; Tsinghua-Peking Center for Life Sciences, Beijing, China; School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:
Bearing a relatively large single-stranded RNA genome in nature, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes sophisticated replication/transcription complexes (RTCs), mainly composed of a network of nonstructural proteins and nucleocapsid protein, to establish efficient infection. In this study, we develop an innovative interaction screening strategy based on phase separation in cellulo, namely compartmentalization of protein-protein interactions in cells (CoPIC). Utilizing CoPIC screening, we map the interaction network among RTC-related viral proteins.
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