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Prevalence of Salmonella and Shigella species and their multidrug resistance patterns among pediatric populations in Ethiopia: a systematic review and meta-analysis.
BMC Infect Dis
January 2025
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, P.O. Box: 1145, Ethiopia.
Background: Salmonella and Shigella are major enteric pathogens that cause diarrhea in children worldwide. They are pathogenic microbes that cause significant diarrheal morbidity and mortality in under five children in resource limited countries. Thus, this systemic review and meta-analysis aimed to investigate the prevalence of Salmonella and Shigella species and their multidrug resistance patterns in pediatric populations in Ethiopia.
View Article and Find Full Text PDFThe Impact of , , and in Diarrheal Infections in Central Africa (1998-2022): A Systematic Review.
Int J Environ Res Public Health
December 2024
Bacteriology Laboratory, Medical Analysis Research Unit, Interdisciplinary Center for Medical Research of Franceville (CIRMF), Franceville BP 769, Gabon.
Background: Gastric diseases caused, in particular, by , non-typhoidal , and resulting from food and/or water problems, are a disproportionately distributed burden in developing countries in Central Africa. The aim of this work was to compile a list of studies establishing the prevalence of the involvement of these bacterial genera in diarrheal syndromes in Central Africa from 1998 to 2022.
Methods: The Preferred Reporting Articles for Systemic Reviews and Meta-Analyses, six (6) database (Pubmed, Google Scholar, Semantic Scholar, Freefullpdf, and Scinapse) were perused for research on the role of , and diarrheal infections in humans and animals, in 9 country of Central Africa over from 1998 to 2022.
D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation.
Immun Inflamm Dis
December 2024
Department of Clinical Laboratory, Zhongshan Second People's Hospital, Zhongshan, Guangdong, China.
Objective: To elucidate the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in the antituberculosis (anti-TB) immune response mediated by dendritic cells (DCs).
Methods: In vivo, C57BL/6J mice infected with the Mycobacterium tuberculosis strain H37Rv. Before infection, the mice were pretreated with the PC-PLC inhibitor D609.
Characterization of serotype 6 strains from geographically diverse low- and middle-income countries.
mBio
January 2025
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Article Synopsis
- Serotype 6 is a common cause of moderate to severe diarrhea but remains understudied, prompting research into its genomic and phenotypic characteristics compared to other serotypes.
- Genomic analyses revealed notable similarities among 6 strains across different regions and timeframes, along with the identification of a potential novel virulence factor and unique patterns of antibiotic susceptibility specific to geographic locations.
- Findings suggest that serotype 6 has distinct genetic and phenotypic traits that could enhance vaccine development and diagnostic tools, which is crucial given the rising incidence of shigellosis, particularly in low- and middle-income countries.
Impact of histopathological and serological assessments on early diagnosis of leprosy relapse.
APMIS
January 2025
National Reference Center for Leprosy/Dermatological Health (CREDESH), HC-UFU/EBSERH, Uberlândia, Brazil.
This study aimed to identify laboratory factors predicting leprosy relapse (LR) after multi-drug therapy (MDT). A case-control study included 80 patients treated with MDT at a national reference center over 12 years. The Relapse Group had 40 patients who relapsed after an average of 89.
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