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Performance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort. | LitMetric

AI Article Synopsis

  • The study evaluated the effectiveness of a new liquid chromatography-mass spectrometry method for measuring plasma Aβ42/Aβ40 as a potential biomarker for PET scan status in a Korean population.
  • Involving 580 participants from various cognitive conditions, the results indicated lower plasma Aβ42/Aβ40 levels in individuals with Alzheimer's disease and related conditions who tested positive on PET scans, with significant predictive accuracy.
  • The novel method demonstrated strong performance in distinguishing PET positivity, achieving an area under the ROC curve of 0.814, improved to 0.912 when considering additional factors like age and diagnosis.

Article Abstract

Background: We assessed the feasibility of plasma Aβ42/Aβ40 determined using a novel liquid chromatography-mass spectrometry method (LC-MS) as a useful biomarker of PET status in a Korean cohort from the DPUK Study.

Methods: A total of 580 participants belonging to six groups, Alzheimer's disease dementia (ADD, n = 134), amnestic mild cognitive impairment (aMCI, n = 212), old controls (OC, n = 149), young controls (YC, n = 15), subcortical vascular cognitive impairment (SVCI, n = 58), and cerebral amyloid angiopathy (CAA, n = 12), were included in this study. Plasma Aβ40 and Aβ42 were quantitated using a new antibody-free, LC-MS, which drastically reduced the sample preparation time and cost. We performed receiver operating characteristic (ROC) analysis to develop the cutoff of Aβ42/Aβ40 and investigated its performance predicting centiloid-based PET positivity (PET+).

Results: Plasma Aβ42/Aβ40 were lower for PET+ individuals in ADD, aMCI, OC, and SVCI (p < 0.001), but not in CAA (p = 0.133). In the group of YC, OC, aMCI, and ADD groups, plasma Aβ42/Aβ40 predicted PET+ with an area under the ROC curve (AUC) of 0.814 at a cutoff of 0.2576. When adding age, APOE4, and diagnosis, the AUC significantly improved to 0.912.

Conclusion: Plasma Aβ42/Aβ40, as measured by this novel LC-MS method, showed good discriminating performance based on PET positivity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540152PMC
http://dx.doi.org/10.1186/s13195-021-00911-7DOI Listing

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