AI Article Synopsis
- Hesperidin and Hesperetin, flavanones found in citrus fruits, have demonstrated antiviral properties against arboviruses like Dengue, Yellow Fever, and West Nile Virus.
- Both compounds inhibit the NS2B/NS3 proteases of these viruses noncompetitively, with Hesperidin showing an IC value under 5 µM and Hesperetin under 70 µM.
- The study suggests that these flavonoids can be optimized for developing new anti-flavivirus medications due to their effective dissociation constants well below 30 µM.
Article Abstract
Ubiquitous in citrus plants, Hesperidin and Hesperetin flavanones possess several biological functions, including antiviral activity. Arbovirus infections pose an ever-increasing threat to global healthcare systems. Among the severe arboviral infections currently known are those caused by members of the Flavivirus genus, for example, Dengue Virus-DENV, Yellow Fever Virus-YFV, and West Nile Virus-WNV. In this study, we characterize the inhibitory effect of Hesperidin and Hesperetin against DENV2, YFV, and WNV NS2B/NS3 proteases. We report the noncompetitive inhibition of the NS2B/NS3 by the two bioflavonoids with half maximal inhibitory concentration (IC) values <5 µM for HST and <70 µM for HSD. The determined dissociation constants (K) of both flavonoids is significantly below the threshold value of 30 µM. Our findings demonstrate that a new generation of anti-flavivirus drugs could be developed based on selective optimization of both molecules.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539695 | PMC |
| http://dx.doi.org/10.3390/plants10102183 | DOI Listing |
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