AI Article Synopsis
- L. (Priprioca) is a plant from the Amazon known for its traditional medicinal uses, and its essential oil contains various terpene compounds, but there's limited information on the solid waste from its oil extraction.
- This study examined the chemical makeup of these solid residues and tested their potential to inhibit cancer cell growth using mouse and human cell models.
- Findings revealed that the ethanolic extract from the solid waste decreases cancer cell proliferation with minimal toxicity to healthy cells, suggesting potential therapeutic applications.
Article Abstract
L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of L. reduced the activity of the enzyme arginase and proliferation of cancer cells ( < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL ( < 0.0001). The results indicated that the extract of L. exerts antiproliferative activity ( < 0.0001) with low toxicity on healthy cells in experimental models in vitro.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541438 | PMC |
| http://dx.doi.org/10.3390/plants10102084 | DOI Listing |
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