AI Article Synopsis
- A new set of Knoevenagel adducts with two indolinone systems was created and tested against 60 human cancer cell lines, following National Cancer Institute protocols.
- Certain derivatives were found to be highly effective in inhibiting cell growth, with growth inhibition (GI) values in the submicromolar range.
- The most effective compound was further analyzed in Jurkat cells to assess its impact on cell-cycle phases and the specific type of cell death it causes, along with studies on oxidative stress and DNA damage.
Article Abstract
A series of new Knoevenagel adducts, bearing two indolinone systems, has been synthesized and evaluated on 60 human cancer cell lines according to protocols available at the National Cancer Institute (Bethesda, MD, USA). Some derivatives proved to be potent antiproliferative agents, showing GI values in the submicromolar range. Compound emerged as the most active and was further studied in Jurkat cells in order to determine the effects on cell-cycle phases and the kind of cell death induced. Finally, oxidative stress and DNA damage induced by compound were also analyzed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537952 | PMC |
| http://dx.doi.org/10.3390/molecules26206277 | DOI Listing |
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