AI Article Synopsis
- Medical device-related infections, especially in cardiovascular implants and catheters, pose significant treatment challenges and are linked to high patient risks.
- Antimicrobial materials could help reduce these infections and improve existing treatment options.
- The study introduces a simple in vivo mouse model that mimics catheter-related infections and allows for testing of antimicrobial materials, examining both local tissue responses and systemic reactions to bacteria in the bloodstream.
Article Abstract
Medical device-related infections are becoming a steadily increasing challenge for the health care system regarding the difficulties in the clinical treatment. In particular, cardiovascular implant infections, catheter-related infections, as well as infective endocarditis are associated with high morbidity and mortality risks for the patients. Antimicrobial materials may help to prevent medical device-associated infections and supplement the currently available therapies. In this study, we present an easy-to-handle and simplified in vivo model to test antimicrobial materials in the bloodstream of mice. The model system is composed of the implantation of a bacteria-laden micro-stent scaffold into the murine tail vein. Our model enables the simulation of catheter-related infections as well as the development of infective endocarditis specific pathologies in combination with material testing. Furthermore, this in vivo model can cover two phases of the biofilm formation, including both the local tissue response to the bacterial biofilm and the systemic inflammatory response against circulating bacteria in the bloodstream that detached from a mature biofilm.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533524 | PMC |
| http://dx.doi.org/10.3390/biomedicines9101464 | DOI Listing |
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