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Use of steroids in COVID-19 patients: A meta-analysis. | LitMetric

Use of steroids in COVID-19 patients: A meta-analysis.

Eur J Pharmacol

Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, 110017, India. Electronic address:

Published: January 2022

AI Article Synopsis

  • * Analysis included data from over 9,900 patients across 21 studies, revealing that steroids significantly reduced death rates compared to non-steroidal treatments.
  • * While results highlighted methylprednisolone as particularly effective, further research is needed to confirm the benefits of other steroids like dexamethasone and hydrocortisone.

Article Abstract

Background: Emerging reports have shown the benefits of steroids in hospitalized COVID-19 patients as life-saving drugs. However, the use of steroids in COVID-19 patients is confusing among many physicians.

Aim: The aim of the current study was to find out the exact association of steroids in the deaths of COVID-19 patients.

Methods: The relevant studies were searched in PubMed, Google scholar, and Clinical trials registries till May 25, 2021 and sorted out based on inclusion and exclusion criteria. The quality of studies was assessed using a standard scale. The pooled odds ratio was calculated with a 95% confidence interval. The sensitivity and sub-group analyses were also done. The publication bias was assessed qualitatively. The Rev Man 5 was used for all analyses with a random-effect model.

Results: The quantitative analysis was done with 9922 patients (6265-male and 3657-females) from 21 relevant studies. The pooled estimate results i.e. 0.52 [0.34, 0.80] have shown a significant reduction in deaths of COVID-19 patients in the steroidal group as compared to the non-steroidal group. The sensitivity analyses did not alter our conclusions. In subgroup analysis, methylprednisolone has shown a significant reduction in deaths of COVID-19 patients as compared to the non-steroidal group, however, more clinical evidence is required for dexamethasone and hydrocortisone.

Conclusion: The use of steroids in hospitalized COVID-19 patients is useful to reduce deaths.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525014PMC
http://dx.doi.org/10.1016/j.ejphar.2021.174579DOI Listing

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