AI Article Synopsis
- Rapid detection of nerve agent threats is crucial for effective countermeasures, highlighting the need for advanced sensing technologies.
- This research introduces a new zirconium metal-organic framework (MIP-202(Zr)) that offers improved catalytic capabilities for detecting and degrading diisopropylfluorophosphate (DFP), a nerve agent simulant, compared to traditional catalysts.
- The study demonstrates that the MIP-202(Zr) sensor has exceptional stability and efficiency, making it suitable for real-time, wearable applications in real-world environments to combat nerve agent threats.
Article Abstract
Rapid and robust sensing of nerve agent (NA) threats is necessary for real-time field detection to facilitate timely countermeasures. Unlike conventional phosphotriesterases employed for biocatalytic NA detection, this work describes the use of a new, green, thermally stable, and biocompatible zirconium metal-organic framework (Zr-MOF) catalyst, MIP-202(Zr). The biomimetic Zr-MOF-based catalytic NA recognition layer was coupled with a solid-contact fluoride ion-selective electrode (F-ISE) transducer, for potentiometric detection of diisopropylfluorophosphate (DFP), a F-containing G-type NA simulant. Catalytic DFP degradation by MIP-202(Zr) was evaluated and compared to the established UiO-66-NH catalyst. The efficient catalytic DFP degradation with MIP-202(Zr) at near-neutral pH was validated by P NMR and FT-IR spectroscopy and potentiometric F-ISE and pH-ISE measurements. Activation of MIP-202(Zr) using Soxhlet extraction improved the DFP conversion rate and afforded a 2.64-fold improvement in total percent conversion over UiO-66-NH. The exceptional thermal and storage stability of the MIP-202/F-ISE sensor paves the way toward remote/wearable field detection of G-type NAs in real-world environments. Overall, the green, sustainable, highly scalable, and biocompatible nature of MIP-202(Zr) suggests the unexploited scope of such MOF catalysts for on-body sensing applications toward rapid on-site detection and detoxification of NA threats.
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| http://dx.doi.org/10.1021/jacs.1c08356 | DOI Listing |
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