A systematic chemical investigation of the deep-sea-derived fungus MCCC 3A00215 resulted in the isolation of one novel polyketide (), two new alkaloids ( and ), and 22 known (-) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol () displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC values of around 20 μM. Moreover, displayed potent in vitro anti-food allergic activity with an IC value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester () and penicopeptide A () showed moderate effects (IC = 50 and 58 μM, respectively).
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| http://dx.doi.org/10.3390/md19100580 | DOI Listing |
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