Saliniquinone Derivatives, Saliniquinones G-I and Heraclemycin E, from the Marine Animal-Derived HDN19-252.

Four new anthraquinone derivatives, namely saliniquinones G-I (-) and heraclemycin E (), were obtained from the Antarctic marine-derived actinomycete HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds and showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.