Study Objectives: Suboptimal sleep is associated with obesity and its sequelae in children and adults. However, few studies have examined the association between sleep and physical growth in infants who experience rapid changes in sleep/wake patterns. We examined the longitudinal association of changes in objectively assessed sleep/wake patterns with changes in growth between ages 1 and 6 months.
Methods: We studied 298 full-term infants in the longitudinal Rise & SHINE cohort study. Changes from 1 and 6 months in nighttime sleep duration, wake after sleep onset (WASO), and number of waking bouts ≥5 min were assessed using ankle actigraphy. Overweight was defined as age- and sex-specific weight for length ≥95th percentile. Generalized estimating equation analyses adjusted for infants' and mothers' characteristics.
Results: The mean (SD) birth weight was 3.4 (0.4) kg; 48.7% were boys. In multivariable adjusted models, each 1-h increase in nighttime sleep duration between months 1 and 6 was associated with a 26% decrease in the odds of overweight from 1 to 6 months (odds ratio [OR] = 0.74; 95% confidence interval [CI, 0.56, 0.98]). Each 1-unit decrease in number of waking bouts was associated with a 16% decrease in the odds of overweight (OR = 0.84; 95% CI [0.72, 0.98]). Changes in WASO were not associated with the odds of overweight.
Conclusions: Greater increases in nighttime sleep duration and more consolidation of nighttime sleep were associated with lower odds of overweight from 1 to 6 months. Adverse sleep patterns as early as infancy may contribute to excess adiposity.
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http://dx.doi.org/10.1093/sleep/zsab243 | DOI Listing |
Sleep Health
January 2025
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Objectives: To describe sleep duration, adherence to sleep recommendations, and behavioral and sociodemographic correlates of sleep among Samoan children.
Methods: In a longitudinal cohort study of Samoan children aged 2-9years (n = 481; 50% female), primary caregivers reported usual number of hours of nighttime sleep during 2015, 2017/2018, and 2019/2020 data collection waves. Associations between behavioral and sociodemographic characteristics and sleep duration were assessed using generalized linear and mixed effect regressions.
Alzheimers Dement
December 2024
Columbia University, New York, NY, USA.
Background: As high as 50% of Alzheimer's disease (AD) patients experience "sundowning", which refers to an increased severity of neuropsychiatric symptoms (NPS), including agitation, confusion, and anxiety, selectively in the evening. Although sundowning significantly influences the decision to institutionalize patients, few preclinical models of this phenomenon exist and the underlying neural mechanisms are unknown. Here, we establish a model of sundowning by phenotyping the sleep-wake cycle and anxiety and exploratory behavior at different times of day in an AD mouse model.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
NIA-Layton Aging & Alzheimer's Disease Research Center, Portland, OR, USA.
Background: Agitation is one of the most challenging behaviors exhibited by people with cognitive decline, causing distress in caregivers, earlier placement into long-term care and faster disease progression. In order to better manage agitated behaviors in people with cognitive decline, it is important to identify associated factors. The MODERATE (Monitoring Dementia-Related Agitation Using Technology Evaluation) study aims to characterize agitation using technology and identify precipitants (behavioral or environmental) of agitation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Penn Alzheimer's Disease Research Center, University of Pennsylvania, Philadelphia, PA, USA.
Background: This study assesses the sensitivity of the mobile cognitive app performance platform (mCAPP), a mobile and engaging cognitive assessment tool, to participant sleep duration.
Method: The mCAPP includes three gamified tasks: a memory task ("Concentration"), a stroop-like task ("Brick Drop"), and a digit-symbol coding-like task ("Space Imposters"). For all games, shorter reaction times and fewer guesses indicates better performance.
Ann Med
December 2025
Department of Ophthalmology, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Objective: This study aimed to assess the associations between multidimensional sleep features and type 2 diabetes mellitus (T2DM).
Methods: We conducted a systematic search across the PubMed, Embase, Web of Science, and Scopus databases for observational studies examining the association between nighttime sleep duration, nighttime sleep quality, sleep chronotype, and daytime napping with type 2 diabetes mellitus (T2DM), up to October 1, 2024. If < 50%, a combined analysis was performed based on a fixed-effects model, and vice versa, using a random-effects model.
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