Meniscus fibrochondrocytes (MFCs) are an important cell population responsible for regulating the biomechanical properties of the knee meniscus. Despite their significance, not much is known about them, including how they sense and respond to mechanical stimuli. Due to the mechanical nature of the knee joint, it is therefore paramount to our understanding of the meniscus that its mechanotransductive mechanism be elucidated. In this review, we will summarize the current knowledge on mechanotransduction in MFCs and highlight the relevance of caveolae in lieu of a recent discovery. Additionally, we will discuss the importance of future studies in this area to help advance the field of meniscus research.
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Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
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Article Synopsis
- - The meniscus is a crucial fibrocartilage tissue in the knee that helps absorb shock during movement, but it has limited healing ability, leading to meniscectomy as a common treatment.
- - A study shows that the endothelial mesenchymal transition (EndMT) plays a role in meniscal regeneration, stimulated by mechanical forces and TGF-β2 signaling.
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