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http://dx.doi.org/10.3389/fpls.2021.767324 | DOI Listing |
J Mol Biol
January 2025
School of Mathematics and Physics, University of Science and Technology Beijing, Beijing, 100083, China. Electronic address:
Single-cell RNA sequencing (scRNA-seq) analysis offers tremendous potential for addressing various biological questions, with one key application being the annotation of query datasets with unknown cell types using well-annotated external reference datasets. However, the performance of existing supervised or semi-supervised methods largely depends on the quality of source data. Furthermore, these methods often struggle with the batch effects arising from different platforms when handling multiple reference or query datasets, making precise annotation challenging.
View Article and Find Full Text PDFPharmaceutics
December 2024
Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia.
Since its discovery more than 100 years ago, photodynamic therapy (PDT) has become a potent strategy for the treatment of many types of cancer [...
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Computer Science, University of Victoria, Victoria, BC, Canada.
Introduction: Accurate genotyping of Killer cell Immunoglobulin-like Receptor (KIR) genes plays a pivotal role in enhancing our understanding of innate immune responses, disease correlations, and the advancement of personalized medicine. However, due to the high variability of the KIR region and high level of sequence similarity among different KIR genes, the generic genotyping workflows are unable to accurately infer copy numbers and complete genotypes of individual KIR genes from next-generation sequencing data. Thus, specialized genotyping tools are needed to genotype this complex region.
View Article and Find Full Text PDFFront Neurosci
December 2024
The Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Türkiye.
Smart city development is a complex, transdisciplinary challenge that requires adaptive resource use and context-aware decision-making practices to enhance human functionality and capabilities while respecting societal and environmental rights, and ethics. There is an urgent need for action in cities, particularly to (i) enhance the health and wellbeing of urban residents while ensuring inclusivity in urban development (e.g.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
December 2024
Institute of Reproductive Developmental Biology, Department of Metabolism Digestion and Reproduction, Hammersmith Campus, Imperial College London, London, W12 0HS, United Kingdom. Electronic address:
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