Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2021-217870DOI Listing

Publication Analysis

Top Keywords

paediatric sarcoidosis
16
exposure inorganic
8
inorganic particles
8
scd controls
8
paediatric
4
particles paediatric
4
sarcoidosis
4
sarcoidosis pediasarc
4
pediasarc study
4
study inorganic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!