AI Article Synopsis
- - Despite advancements in medications for lipid disorders, many patients with heterozygous Familial Hypercholesterolemia still struggle to reach target cholesterol levels, increasing their risk of heart disease.
- - This study examines the combination of Lipoprotein apheresis (LA) and PCSK9 inhibitors (PCSK9i) in patients who haven't met recommended cholesterol targets over the course of a year.
- - Results indicate that this combined therapy could potentially allow more patients to receive LA treatment, improve their quality of life, and lower overall treatment costs per patient.
Article Abstract
Despite advance in pharmacotherapy of lipid disorders, many heterozygous Familial Hypercholesterolemia patients do not achieve a desirable lipid target to significantly reduce the risk of atherosclerotic cardiovascular disease. The aim of the present work is to evaluate the interaction between Lipoprotein apheresis (LA) and PCSK9i in a small FH cohort in which the guidelines therapeutic target is not achieved. During one year, together with a complete adherence to PCSK9i therapy, we recorded a 3 to 5 LA sessions less per year in each patient. This therapeutic approach suggests: i) the possibility of increasing the number of patients treated with LA, ii) the improvement of their quality of life, and iii) the costs reduction for the single patient-treatment.
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| http://dx.doi.org/10.1016/j.transci.2021.103258 | DOI Listing |
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