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A review of the pathophysiology of recurrent implantation failure. | LitMetric

A review of the pathophysiology of recurrent implantation failure.

Fertil Steril

IVIRMA of New Jersey, Basking Ridge, New Jersey; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.

Published: December 2021

AI Article Synopsis

  • Implantation is an important part of having a baby, where the embryo connects to the mother’s womb after fertilization.
  • Sometimes, embryos don’t stick to the womb as they should, which is called recurrent implantation failure, and this can happen even after trying multiple times.
  • Researchers are studying many reasons for this failure, like genetics, the mother’s immune system, and other health factors, but there isn’t one simple solution yet.

Article Abstract

Implantation is a critical step in human reproduction. The success of this step is dependent on a competent blastocyst, receptive endometrium, and successful cross talk between the embryonic and maternal interfaces. Recurrent implantation failure is the lack of implantation after the transfer of several embryo transfers. As the success of in vitro fertilization has increased and failures have become more unacceptable for patients and providers, the literature on recurrent implantation failure has increased. While this clinical phenomenon is often encountered, there is not a universally agreed-on definition-something addressed in an earlier portion of this Views and Reviews. Implantation failure can result from several different factors. In this review, we discuss factors including the maternal immune system, genetics of the embryo and parents, anatomic factors, hematologic factors, reproductive tract microbiome, and endocrine milieu, which factors into embryo and endometrial synchrony. These potential causes are at various stages of research and not all have clear implications or immediately apparent treatment.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2021.09.014DOI Listing

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