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Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma. | LitMetric

AI Article Synopsis

  • - The study focuses on identifying key genes related to hepatocellular carcinoma (HCC) to improve diagnosis, prognosis, and develop therapeutic strategies.
  • - High levels of CDK1, CCNB1, and CCNB2 in HCC patients correlate with poor prognosis, and reducing their expression induces cell aging and self-digestion.
  • - Lycorine shows potential as a treatment by reducing CDK1 levels, suggesting it could interact with CDK1 to enhance HCC therapy and position CDK1 as a target for future treatments.

Article Abstract

The pathological changes and possible underlying molecular mechanisms of hepatocellular carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains a challenge. The purpose of this study is to obtain some key genes with diagnostic and prognostic meaning and to identify potential therapeutic agents for HCC treatment. Here, CDK1, CCNB1 and CCNB2 were found to be highly expressed in HCC patients and accompanied by poor prognosis, and knockdown of them by siRNA drastically induced autophagy and senescence in hepatoma cells. Simultaneously, the anti-HCC effect of lycorine was comparable to that of interfering with these three genes, and lycorine significantly promoted the decrease both in protein and mRNA expression of CDK1. Molecular validation mechanistically demonstrated that lycorine might attenuate the degradation rate of CDK1 via interaction with it, which had been confirmed by cellular thermal shift assay and drug affinity responsive targets stability assay. Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.

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Source
http://dx.doi.org/10.1016/j.bcp.2021.114806DOI Listing

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