AI Article Synopsis
- Pluripotent cells in mammalian embryos go through distinct stages, altering their gene expression and developmental capabilities during early development phases before and after implantation.
- Studies on cultured mouse and human pluripotent stem cells have discovered an intermediate stage called the "formative state," bridging naive and primed pluripotency.
- The research explores these findings in relation to mouse and human development and discusses how they might inform the creation of human embryo models using pluripotent cells.
Article Abstract
Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developmental potential as they progress from pre-implantation through post-implantation stages of development. Recent studies of cultured mouse and human pluripotent stem cells (hPSCs) have identified cells representative of an intermediate stage (referred to as the formative state) between naive pluripotency (equivalent to pre-implantation epiblast) and primed pluripotency (equivalent to late post-implantation epiblast). We examine these recent findings in light of our knowledge of peri-implantation mouse and human development, and we consider the implications of this work for deriving human embryo models from pluripotent cells.
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| http://dx.doi.org/10.1016/j.stem.2021.10.001 | DOI Listing |
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