Leaders of the world's major economies, representing 80% of the world's gross domestic product, will meet at the end of this month at the G20 meeting in Rome to address issues of global importance, including how to increase the worldwide supply of COVID-19 vaccines. How the world addresses the current state of vaccine inequity will affect how we meet future global disease challenges.
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http://dx.doi.org/10.1126/science.abm8724 | DOI Listing |
Lancet
January 2025
Executive Committee, Regionalized Vaccine Manufacturing Collaborative (RVMC), Oslo, Norway.
J Infect Dis
January 2025
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
The global outbreak of clade IIb mpox in 2022-2023 changed our understanding of the epidemiology and prevention of mpox, simultaneously highlighting inequities in access to vaccines, diagnostics, and therapeutics. With the recent multinational spread of clade Ib mpox, it is important to revisit these lessons to improve future response. In September 2024, an international mpox symposium was held at Johns Hopkins University to discuss what we have learned and how to better prepare for the future.
View Article and Find Full Text PDFVaccine
January 2025
Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Canada. Electronic address:
Neisseria gonorrhoeae, which causes the sexually transmitted infection gonorrhea and Neisseria meningitidis, a leading cause of bacterial meningitis and septicemia, are closely related human-restricted pathogens that inhabit distinct primary mucosal niches. While successful vaccines against invasive meningococcal disease have been available for decades, the rapid rise in antibiotic resistance has led to an urgent need to develop an effective gonococcal vaccine. Several surface antigens are shared among these two pathogens, making cross-species protection an exciting prospect.
View Article and Find Full Text PDFmBio
January 2025
Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Unlabelled: The KREMEN1 (KRM1) protein is a cellular receptor for multiple enteroviruses that cause hand, foot, and mouth disease (HFMD), including coxsackievirus CVA2, CVA3, CVA4, CVA5, CVA6, CVA10, and CVA12. The molecular basis for the broad recognition of these viruses by the KRM1 receptor remains unclear. Here, we report the indispensable role of the completely conserved VP2 capsid protein residue K140 (designated K2140) in mediating receptor recognition and infection by CVA10 and other KRM1-dependent enteroviruses.
View Article and Find Full Text PDFExplor Res Clin Soc Pharm
March 2025
Equipe ThEMAS, Univ. Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, 38000 Grenoble, France.
Objective: Pharmacy work encompasses two main streams. These are logistic flow (the supply and distribution of healthcare products) and pharmaceutical flow (the dispensing and provision of pharmacy services). The pharmaceutical flow has increased significantly with the introduction of reimbursed services such as Rapid Diagnostic Tests, chronic disease screening, minor ailment prescriptions, vaccine prescription and administration, and medication reviews.
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