AI Article Synopsis
- * A case study describes a 68-year-old man with symptomatic epilepsy post-cerebral infarction who had a very limited length of intact jejunum due to previous surgery.
- * The patient showed effective absorption of VPA and LEV despite his short-bowel syndrome, indicating that these medications can still be beneficial in such conditions.
Article Abstract
Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment. However, their use to treat short-bowel syndrome has not been reported. We herein report a 68-year-old man who was hospitalized for symptomatic epilepsy following cerebral infarction. He had a history of superior mesenteric arterial occlusion, and only 30 cm of his jejunum was intact. VPA and LEV were administered, and good blood levels were achieved at clinical doses. This suggests that the gastrointestinal tract absorption of LEV and VPA is good even in patients with short-bowel syndrome and a 30-cm jejunum.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152876 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.7622-21 | DOI Listing |
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