BP-180-specific IgG antibodies: A potential useful candidate for early diagnosis of Bullous pemphigoid during anti-PD-1/anti-PDL-1 of melanoma patients.

Med Hypotheses

National and Kapodistrian University of Athens Faculty of Medicine, 1st Department of Dermatology Venereology, Andreas Sygros Hospital, Athens, Greece.

Published: December 2021

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http://dx.doi.org/10.1016/j.mehy.2021.110703DOI Listing

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Background: Prodromal bullous pemphigoid (PBP) and bullous pemphigoid (BP) demonstrate immunoglobulin G (IgG) and/or C3 deposition at the basement membrane zone (BMZ) on direct immunofluorescence. BP-180-specific IgG1, IgG4, and IgE antibodies have been detected in BP. However, the distribution of IgG subclasses is unknown in PBP.

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