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The role of epidemiologists in addressing the public health consequences of the United States criminal legal system.
Am J Epidemiol
January 2025
Department of Public Health Leadership and Practice, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Exposure to the United States criminal legal system - whether through contact with law enforcement, incarceration in a jail or prison, or community supervision - is associated with a range of adverse health outcomes. There is mounting evidence that mass incarceration drives health inequities, particularly for Black, Indigenous, and People of Color. However, relative to its outsized impacts on health and health inequities, the criminal legal system has received limited attention in epidemiology.
View Article and Find Full Text PDFWhen HSFs bring the heat-mapping the transcriptional circuitries of HSF-type regulators in .
mSphere
December 2024
Institut Pasteur de Tunis, University of Tunis El Manar, Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, Tunis, Tunisia.
Heat shock factor (HSF)-type regulators are stress-responsive transcription factors widely distributed among eukaryotes, including fungi. They carry a four-stranded winged helix-turn-helix DNA-binding domain considered as the signature domain for HSFs. The genome of the opportunistic yeast encodes four HSF members, namely, Sfl1, Sfl2, Skn7, and the essential regulator, Hsf1.
View Article and Find Full Text PDFInvolving stakeholders with lived and professional experience in a realist review of community mental health crisis services: a commentary.
Res Involv Engagem
December 2024
Lived Experience Stakeholder, Leeds, UK.
Patient and Public Involvement (PPI) is considered good practice in all health research including literature reviews. Reporting of involvement practice in realist reviews has been inconsistent leaving gaps in understanding of best practice. Realist reviews are theory driven and explain how interventions work, for whom and in which circumstances.
View Article and Find Full Text PDFMolecular insights unlocking therapeutic potential for multiple myeloma and bone disease management.
J Exp Clin Cancer Res
December 2024
Department of Health Sciences, Magna Graecia University of Catanzaro, 88100, Catanzaro, Italy.
Multiple myeloma (MM), a hematologic malignancy characterized by the clonal expansion of plasma cells within the bone marrow, is associated with severe health complications, including osteolytic bone lesions that significantly increase the risk of fractures, leading to higher morbidity and mortality rates. One intriguing protein in this context is the RNA polymerase binding factor Che-1/AATF (Che-1), which has emerged as a potential player in the survival and proliferation of myeloma cells. Hippo pathway has been shown to be an important mediator of oncogenesis in solid tumors, especially for its role in shaping a tumor microenvironment favorable to cancer maintenance and spread.
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